(109) Cholera in Bengal Proper in 1876. The high mortality reached in November and December this year is not usual in Bengal, and is attributed to the effects of the cyclone in the Eastern Bengal. These diagrams show that in Bengal and Orissa, consisting of flat low-lying, muddy plains, the former intersected by the lower course of the Ganges and Brahmaputra, and the latter by the Maha- naddi-there are two periods in which cholera prevails with great severity, viz., from March to May in Bengal and March to July in Orissa, during which it attains maximum intensity; and again from October to December in both Bengal and Orissa, when it prevails with diminished severity, and that the remaining months are months of subsidence after each period of its seasonal activity. That in Bihar and Chota Nagpur, both of which are comparatively high and dry, there is only one period of intense prevalence of cholera; viz., from March to July in Bihar and March to August in Chota Nagpur; and that during the remaining months the prevalence of the disease is com- paratively mild. That, as a general rule, the disease prevails least when the rainfall is heaviest, and has submerged or is moving on through the country, particularly in Bengal. "Whether cholera has a special poison of its own, has not yet been demonstrated. If there be one, it is not communicable ordinarily from the living subject, first, because inoculation with fresh cholera secretions or excretions does not induce it; second, because those who rub cholera patients' skins, wash their clothes, scrape up, clean, carry, and bury their excreta, or dissect, carry, and bury the cholera corpses, do not get it; and lastly, cholera-collapsed mothers do not com- municate the disease to their sucking infants; though the latter pull at their breasts, lie on their sweat-covered arms, and on their soiled clothes and bedding. That cholera evacuations, whether in clothes, soil, water, food, &c., do become virulent, and do, especially when taken into the system by the mouth, give rise to cholera, I have no manner of doubt; but I am equally satisfied that cholera constantly arises de novo, and that in both cases the disease is intimately connected with the changes that occur in decaying organic matters. The most ready entrance of the disease into the system is by water impregnated with decaying organic matters. This water soon loses this power when the decaying changes are completed, and re-acquires it when fresh decaying matters find their way into it. I do not know of any of the phenomena associated with the origin and spread, the seasonal and local prevalence of, and the persons affected with the disease, with which the