( 72 ) CHAPTER IV. Treatment and prevention. Treatment before the diagnosis has been made. IN all diseases associated with fever an accurate diagnosis is essential for successful treatment. During the period which sometimes elapses before accurate diagnosis of the cause of the fever in a patient who complains of this symptom can be made the following line of treatment should be adopted. The patient should be admitted into hospital, sent to bed and given a milk-diet. His temperature should be taken every four hours. Medicinal treatment should be directed to the relief of symptoms; a diaphoretic mixture and a mild purge may be given if indicated, but during this period quinine must on no account be used. Routine treat- ment for adults. This line of treatment will be continued until the diagnosis is assured when, if necessary, it will be changed to one more likely to cure the disease which has been recognised as the cause of the fever. In these notes we have to consider the treatment of those patients only in whose cases a diagnosis of malarial fever has been made. It is well known that quinine is a true specific, that is, an infallible remedy, for this fever. Its administration should be begun immediately the diagnosis is assured, irrespective of the stage of the attack or the height of the fever. A good routine practice in the treatment of adult patients is to give a dose of 15 grains of the sulphate dissolved in two or three ounces of water (with the aid of a sufficient quantity of dilute hydrochloric acid) just before the morning meal and a similar dose before the evening meal, and to continue these doses daily for five days. It is a good practice to give a purgative on the day that the treatment is begun. If it has been possible during the first stage, that is during the days before the diagnosis has been made, to ascertain the time of the day or night at which the paroxysm is to be expected, the times of giving the doses of quinine should be altered, one dose being given about four hours before the expected paroxysm and the other about 12 hours later. Expe- rience has shown that, provided the doses of quinine are not vomited or are not passed through the intestine without being absorbed, there is hardly any form of true malarial fever which fails to yield to this treatment within a few days and if at the end of five days, the patient's fever continues as