56 Infantry Lines suffered severely. Large buildings such as the Crawford Market and Sitaram Buildings appear to have acted as a bar to the diffusion of infection, there being much less sign of malaria immediately due west of them than on the Paltan Road side; but, where the wall of high buildings ceased, infection diffused more deeply into the Esplanade and penetrated as far as the Cama Hospital, the Gokuldas Tejpal Hospital and St. Xavier's College. Further south in the Esplanade the lofty buildings of the Victoria Terminus and the Municipal Offices appear to have checked the diffusion of infection to the west, but all the residents to the east of these buildings suffered severely. The guards, porters and sweepers belonging to the G. I. P. Railway were attacked, and so many of the former were prostrated that at one time during the height of the epidemic as many as ten of the local trains had to be cancelled. St. George's Hospital, which is situated so that it overlooks the new dock-works, became the most malarious place in the City, the members of the nursing staff were frequently prostrated with malaria, and few of the patients who entered the hospital escaped contracting the disease. The portion of the North Fort immediately overlooking the harbour was also seriously affected, but a careful examination of that area shews that, though malaria was intense in Frere Road, there was a marked fall in the amount of infection present, as shewn by the spleen rate, in the area immediately adjoining Mint Road. This appears to indicate that blocks of high buildings in the North Fort formed a barrier and checked the diffusion of malarial infection from the east into that section just as they had evidently done in Chakla. 124. Passing westward from Fere Road into the North Fort, malaria becomes more intense again, but investigation has shewn that this is due not to the diffusion of malaria from the east or harbour side, but to the existence of hundreds of open wells and permanent foci of malarial infection in the Fort itself. A similar centre of infection, due entirely to local causes, is to be found in Dhobi Taláo section, an area situated on the west side of the island far away from the new dock-works. In this case also the local cause of malaria is the presence of hundreds of open house wells in the section; and the same influence may be traced in the Market section to the east of this. 125. It is now evident as a result of numerous observations regarding the distribution of splenic enlargement, malarial infection and local species of anopheles mosquitoes, that all the factors necessary for the continued existence and spread of malaria are to be found in many of the older portions of the City, especially in A. and parts of B. and C. Wards and to a much less extent in D. and E. Wards. And so long as this condition is allowed to exist, the undertaking of any large work necessitating excavation and leading possibly to the encampment for a considerable period of large bodies of coolie labourers on the site of the work, will undoubtedly be followed by a gradual increase of malaria in the adjoining areas, unless the strictest precautions are adopted from the outset. 126. There are strong grounds for believing that the absence of outbreaks of malaria in association with the construction of the Prince's and Victoria Docks years ago and the more recent work at Sewri and the Port Trust Railway was due to the fact that:- (1) No serious centres of malarial infection existed in the vicinity of these works; (2) Few permanent breeding places of dangerous species of anopheles were present in their neighbourhood; (3) The labourers employed were not encamped, in the case of the dock-works, on the site of the works. 127. The sequence of events in connection with the epidemic outbreak of malaria associated with the construction of present new docks appears to have been as follows:- (1) The existence of a serious amount of malarial infection among the residents of North Fort close to the site of the works.