150 The result of experience gained by local, radical or tentative treat- ment of the glands does not lead one to expect much benefit from there. That abscesses should be opened when they point, or when fluctuation is perceptible, is, of course, natural; but that local remedial steps should be undertaken for the purpose of affecting the course of the disease by acting on the gland is, from what we know of the pathology of the disease, scarcely rational. Injection of a swollen gland when it is accessible, as in the groin, with such substances as carbolic acid, per- chloride of mercury, or a solution of the perchloride of mercury and iodide of potassium, has perhaps a theoretical basis of justification, but practically little good can be ascribed to it. The latter-mentioned solution may have a higher claim, as in several cases in which it has been administered temperature falls and the patient seems easier. It may be, however, that the mere pricking of the tense capsule of the gland, even by needle punctures, may serve to relieve tension and thereby pain. This leads one to the belief that subcutaneous incision of the gland may be attended with beneficial results, and it is a method of surgical procedure not without precedent. Early free incision of the gland is not to be recommended, nor can excision be in any way justified. The disease is a polyadenitis, and of so extensive a nature that eradication of infected glands is an impossibility. A gland when swollen, red and painful may be smeared with glycerine and belladonna or poulticed to relieve pain, and when fluctuation is perceptible it should be opened, but further procedure is useless. When pus is evacuated, dusting the wound with iodoform and ensuring thorough drainage are the means by which the best results are obtainable. Retention of Urine, a frequent concomitant during the delirium of plague, renders the use of the catheter imperative." (G.O, No. 298-M., dated 26th February 1897.) 2. Extract from the Report of Major Bannerman, M.D., B.S c., dated 27th March 1897. "It is necessary that a medical officer should be able to recognise at the earliest possible date the occurrence of a case of plague, both for the sake of the patient himself, and for the prevention of the spread of the the infection. In cases presenting the classical signs there can be little difficulty in arriving at a correct diagnosis, but when the glan- dular swellings are absent, as they often are, it may be necessary to keep a patient under observation for some days before a decision can be arrived at. The following signs and symptoms may be regarded as typical :-A rise of temperature on the first day of the disease, of a very pronounced character, 106° or more being common, accompanied by severe shivering and frequent vomiting. In 95 per cent. of the cases the conjunctivæ are found to be injected on the second day of the disease. The tongue may be described as being like wash-leather, or of a rusty brown " typhoid " appearance, with red or even inflamed edges. When spoken to, the person answers in a slow hesitating indistinct manner, the sylla- bles being separated from one another, and the impression conveyed being that the individual is under the influence of alcohol. The gait is also in many cases suggestive, being like that of a drunken man. Some cases, on the other hand, may present violent maniacal symptoms, or the