?16 In places where rats are very numerous plague may develop when climatic conditions are adverse, i.e., when rat-fleas are scarce, but plague tends to disappear with the advent of hot dry weather. It cannot be too strongly emphasized that anti-rat measures, directed towards the eradication of plague infection, can be prosecuted with most chance of success in the hot dry months when plague cases and foci of infection are fewest. The relatively plague-free season should synchronize with maximum anti-plague effort and not be regarded as a suitable time for a cessation of anti-plague measures. Anti-plague measures can be grouped under four heads:- (a) Rat elimination or the prevention of rat infestation. This comprises such modifications in the habits, customs, and dwellings of a community as will result in a diminished rat infestation in the homes of the people and make the association between rats and men less intimate than at present. (b) Measures designed to protect the rat population of any given town or village from plague infection. These entail a clear under- standing of the manner in which plague infection is carried from place to place. (c) Rat destruction designed, as is (a), to diminish the chances of infection, and to keep the rat population at so low a level that is plague be introduced the severity of the resulting epidemic will be appreciably diminished. (d) If our efforts under these three heads fail to keep plague out it is left to try and render the human population immune to attacks of the disease by means of inoculation, or to remove the population at risk from close association with infected rats. The latter involves the evacuation of infected dwellings and the provision of temporary accommodation outside the rat-infested, plague-infected area. Measures included under (a), (b) and (c) can be carried out at any season of the year; measures under (d) are generally applicable only in the plague season. Segregation of the sick is not essential. For all practical purposes the patient suffering from bubonic plague is not capable of infecting those in close attendance on him. Such a statement is not true of pneumonic plague. Small outbreaks of this disease, which is extremely infectious, are occasionally experienced in India. These are, however, of infrequent occurrence and of small moment when compared with the incidence of bubonic plague. It will be noted that of the four 'components' of a plague epidemic, viz., the plague bacillus, the rat-flea, the rat, and man, only the rat and man have been specifically mentioned in this preliminary discussion of preventive measures. The plague bacillus is so short- lived outside the body of either the rat-flea, the rat, or man, that for practical purposes it need not be considered as possessing an independent existence. Similarly, the welfare of the rat-flea is so dependent on the plentiful supply of rats which they parasitize, and has so short a life apart from its proper host, especially if it be infected with plague, that 'anti-flea' measures received no specific mention. Such measures will be referred to when (b) is under detailed consi- deration: they have very decided value and should in no wise be overlooked.