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Medical Officers of the Army of India.

   Symptoms set in two hours later, and death occurred at three hours and
three quarters after the administration of the venom.

   Experiment II. —A fowl received a dose of cobra-venom of equal amount
to that employed in the previous experiment dissolved in 1 C.C. of solution of
antivenene.

   Death occurred three hours and forty minutes later.

   Experiment III. —A fowl received a dose of cobra-venom, amounting to
six and a half times a minimal lethal dose in 1 C.C. of solution of antivenene.
Death occurred five hours later.

   Experiment IV. —A fowl received a minimal lethal dose of cobra-venom in
1 C.C. of solution of antivenene.

   Death occurred five hours later.

   In the first two experiments of this series the duration of life was certainly
abnormally protracted in relation to the amount of venom which was employed,
but the results of the other two experiments appear to indicate that this must
have been merely dependent on obstructed absorption connected with the nature
of the vehicle. In fact, a solution of 0.1 gramme of dry antivenene in 1 C.C.
of water is so very thick and glutinous that it appears to be on the whole more
remarkable that death should have occurred so rapidly as it did in Experiment
IV, in which only a minimal lethal dose of venom was employed, than that it
should have been somewhat postponed in the first two cases.

(b ) EXPERIMENTS IN WHICH THE INJECTION OF MINIMAL LETHAL DOSES
OF COBRA-VENOM WAS FOLLOWED BY THE INTRODUCTION OF
SOLUTIONS OF ANTIVENENE.

(1 ) Cases in which the Venom and the remedy were introduced in the same site.

   Experiment V. —A fowl received a minimal lethal dose of cobra-venom.
Twenty minutes later, 1 C.C. of solution of antivenene was injected into the
same site, and four more doses of 0.5 C.C. were administered within the course
of the following five hours.

   No symptoms of intoxication ever manifested themselves.

   Experiment VI. —A fowl received a minimal lethal dose of dry cobra-venom,
and twenty minutes later, 1 C.C. of solution of antivenene in the same site. Five
more doses of 0.5 C.C. of the solution were administered during the course of
the next three hours.

   Slight symptoms of intoxication appeared six and a half hours after the
beginning of the experiment, but were succeeded by recovery.

(2 ) Cases in which the Venom and the remedy were introduced at sites widely
remote from one another.

   Experiment VII —A fowl received a minimal lethal dose of cobra-venom
in the right leg. Twenty minutes later 1 C.C. of solution of antivenene was

K