25

      Kleine²² gave .5 gramme Quinine bi-hydrochloride subcutaneously to each
of two patients and found the amount eliminated in the first 24 hours in one
case was 11.37 per cent. and in the other 9.70 per cent. To another patient he
gave .5 gramme Quinine hydrochloride, and the amount eliminated in the first
24 hours was 15.32 per. cent. The greater excretion in the last case probably
accompanied a greater absorption due to the greater dilution in which the
hydrochloride was probably given owing to its less solubility. Mariani¹³ tested
the effect of concentration of the Quinine injection on the elimination. In
the one case he injected one gramme of Quinine bi-hydrochloride in ten cubic
centimetres of water and in the other case the same salt and dose in two cubic
centimetres of water: in the former, 13.7 per cent. was eliminated in the first
24 hours; in the latter, 15.791: in the former, elimination was at its height
between the sixth and twelfth hours after injection; in the latter, between
the ninth and eighteeth hours after injection. It is worthy of note that
differences in dilution of 1 in 2 and 1 in 10 had no great influence on the
amount of Quinine excreted and probably absorbed. This agrees with the
results obtained by me in the minimum-lethal dose experiments. Giemsa and
Schaumann,⁵ however, using Quinine urea have obtained very different
results. They carried out two sets of experiments: in one set they adminis-
tered one gramme of Quinine urea in ten cubic centimetres of water to each
patient daily, and in the other set one gramme of Quinine urea in one cubic
centimetre of water daily, with the following tabulated results:—

Table VI.