32
With the object of getting some idea as to the relative promptness of action
attained by the different methods of administration, the time of appearance of
the various toxic symptoms in each experiment was carefully noted,—with the following results.
Table VIII.
Minimum-Lethal Dose Experiments on Guinea = pigs.
Order in which Toxic symptoms Appeared.
(Quinine Bi-Hydrochloride.)
| Time after ad- ministration. |
ORAL ADMINISTRATION. | SUBCUTANEOUS INJECTION. | ||||
| Fasting. Dose= about .45 gm. per kilo. |
With food. Dose =about .5 gm. per kilo. |
1-150. Dose= about .3 gm. per kilo. |
1-2. Dose= about .6 gm. kilo. |
1-8. Dose=about .6 gm. per kilo. |
||
| ¾ | hour. | ... | ... | Unsteadiness. | ... | ... |
| 1 | " | ... | ... | Convulsions | ... | .. |
| 2 | hours. | ... | ... | Inability to stand. |
... | ... |
| 2½ | " | Unsteadiness | ... | ... | ... | ... |
| 3 | " | ... | Unsteadiness | ... | ... | ... |
| 3½ | " | Twitchings and "starts" |
... | ... | ... | ... |
| 4 | " | ... | Twitchings and "starts" |
... | ... | ... |
| 4½ | " | Convulsions | ... | ... | ... | Unsteadiness |
| 5 | " | ... | ... | ... | ... | Twitching and starts. |
| 6 | " | ... | ... | ... | Unsteadiness | ... |
| 6 ½ | " | ... | Convulsions | ... | ... | ... |
| 8 | " | ... | ... | ... | Convulsions | Convulsions |
| Recovery un- der 24 hours if dose sub- lethal. |
Recover un- der 24 hours if dose sub- lethal. |
Recovery under 24 hours if dose sub-lethal. |
Recovery took at least 30 hours if dose sublethal. |
... | ||
From this table it is evident that, as regards promptness of effect, the
various modes of administration stand in exactly the same order as that given
for lethality or absorbability. The time at which the various toxic symptoms
appeared in the case of suicide (already described) by swallowing four drachms
of Quinine, which is about the minimum lethal dose for man, corresponded so