33

closely with that given in this table that probably all the results tabulated
here hold good approximately for man. Other reasons that justify the applica-
tion of this table to man are the following:—

     The maximum elimination of Quinine in man's urine after Quinine by
        the mouth during fasting occurs between the third and sixth hours
        (Mariani¹³).

     The maximum elimination of Quinine in man's urine after Quinine by the
        mouth after food occurs between the sixth and twelfth hours (Mariani ¹³).

     The maximum elimination of Quinine in man's urine after a subcutane-
        ous injection of one gramme of Quinine bi-hydrochloride (1) dissolved in
        ten cubic centimetres of water occurs between the sixth and twelfth
        hours, and (2) dissolved in two cubic centimetres of water occurs
        between the ninth and eighteenth hours (Mariani.¹³).

     These results obtained by Mariani correspond in a very striking manner
with the appearance of convulsions in the guinea-pigs in the minimum-lethal
dose experiments.

     The results tabulated above may therefore be taken as practically conclu-
sive; and they show that the oral administration of Quinine affords more
prompt action of the alkaloid than does the subcutaneous.

     The following curves give a graphic representation of the absorption of
Quinine after administration in the various methods already referred to, the
dose of Quinine being taken to be the same in each case:—

Curves of Quinine Absorption after various Methods
of Administration.

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