286 THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY [ I, IV

after 36 days and thereafter the animal was normal. After 88 days the animal
was re-infected a second time; result negative.

In a later paper, Kligler and Weitzman [1925] published the results of a
further series of three experiments with " Bayer 205 ", and these were as follows:—

Rabbit. 0.05 gramme injected. Infected 35 days later; result negative.

Rabbit. 0.05 gramme injected. Infected 35 days later; result negative.
Infected again after 3 months; result positive, after incubation of 15 days.

Rabbit. Injected 0.1 gramme per kilo. Infected one month later; result
negative. Re-infected after another month; result positive, after an incubation of
3 weeks.

Apart from the fact that these observations furnish useful indications as to the
simple prophylactic value of " Bayer 205 ", they have been regarded by Kligler and
Weitzman as being of considerable significance in relation to the question of the
mechanism of the trypanocidal action of the drug (infra).

Edwards [1928], in India, carried out a series of experiments upon the pro-
phylactic effect of " Bayer 205" in horses against experimental infection with
T. evansi. The results have been summarized in a Table which is reproduced
below:—