330 THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY [ I, IV
TABLE III— conld.
|
Time of Bleeding |
Serum and varying |
Result of Rabbit inocula- |
Rabicidal properties |
|
|
Amount of |
Amount of |
|||
|
23 days |
0.5 |
0.125 |
Lived .... |
}Present in low |
|
0.5 |
0.250 |
Died .... |
||
|
0.5 |
0.500 |
Died .... |
||
|
0.5 |
1.000 |
Died .... |
||
|
37 days . . { |
0.5 |
0.125 |
Lived .... |
} Present+ |
|
0.5 |
0.250 |
Lived .... |
||
|
0.5 |
0.500 |
Died .... |
||
|
0.5 |
1.000 |
Died .... |
||
|
70 days . . { |
0.5 |
0.125 |
Lived .... |
} Present.+ |
|
0.5 |
0.250 |
Lived .... |
||
|
0.5 |
0.500 |
Lived .... |
||
|
0.5 |
1.000 |
Died .... |
||
|
88 days . . { |
0.5 |
0.125 |
Lived .... |
} Disappearing. |
|
0.5 |
0.250 |
Died .... |
||
|
0.5 |
0.500 |
Died .... |
||
|
100 days . . { |
0.5 |
0.125 |
Died .... |
} Nil. |
|
0.5 |
0.250 |
Died .... |
||
From the above Table the results following upon the intracutaneous inocula-
tion of a human case with a 1 per cent, suspension of killed carbolised fixed virus
in a dosage of 5 c. cm. daily on 14 consecutive days (0.7 grammes) may briefly be
summarised:—
(1) Rabicidal properties were absent from the serum 7 and 14 days after the
commencement of treatment (and this was true for the sera of all the eight cases
of wolf.bite treated).
(2) Rabicidal properties were demonstrable in the serum 23 days after the
commencement of treatment, one unit volume of serum neutralising 0.25 volume
of a 1:100 fixed virus suspension in normal saline solution.
(3) Rabicidal antibody content reached a maximum (1:1) some 50 to 60 days
after completion of treatment and thereafter subsided fairly rapidly.
(4) The immune serum retained rabicidal properties for a period of three
months.
It seems, therefore, that although anti-rabies immunity may be fully
developed comparatively little rabicidal antibody production follows the exhibition