CURATIVE TREATMENT OF SURRA IN EQUINES                     93

4.  Four cases were treated with success being discharged as cured within three
weeks. They were however unsound animals and were sent to the Pinjrapole
where two lived for four months and two were lost sight of. None of these had a
relapse as far as our information goes.

5.  Two cases died within 24 hours after the first injection.

6.  The animals noted in paragraphs 4 and 5 were all debilitated animals and
not suitable subjects for treatment at all.

7.  In all cases the Trypanosomes disappeared from the peripheral blood within
24 hours of injection."

II.—TREATMENT OF EQUINE SURRA BY THE INTRAVENOUS INJECTION OF
                    " BAYER 205 " COMBINED WITH OTHER DRUGS.

A number of workers have recorded having obtained very encouraging results
from the use of " Bayer 205 " when used in combination with other drugs, e.g.,
atoxyl and tartar emetic. Except for reasons of cost, there appear to be hardly
any a priori grounds for considering that such a combination should possess any
superiority over any of the drugs used alone. As a matter of fact, some workers
in the Punjab, who have been lately advocating the use of " Bayer 205 " in com-
bination with tartar emetic, have apparently been led to do so by consideration of
cost alone, as would appear from the following statement:—" To reduce the expen-
siveness of the treatment by ' Bayer 105 ' it was suggested to reduce the number
of its doses, and add in its place the doses of tartar emetic, which, like this drug,
has also proved most useful in the treatment of surra" [Kahan Singh, 1927].
However, one other reason that has evidently led to the use of these two drugs in
combination is the drastic nature of the trypanocidal action of tartar emetic which,
as has been mentioned by more than one worker, is liable to produce fatal conse-
quence if injected in the full therapeutic dose in heavy infections.

A detailed consideration of the results obtained by various workers from the
use of " Bayer 205 " in combination with other drugs would be outside the scope
of this paper which is primarily intended to be a résumé of the present position
concerning the value of " Bayer 205 " when used alone. Nevertheless, these results
furnish some indication as to the dosage of the drug that may be employed with
safety, and it is needless to say that, in the uncombined form, the drug would
admit of being used in considerably larger doses.

Perhaps, the most extensive trials as yet carried out with " Bayer 205 " in
combination with other drugs are those of Bubberman, Douwes and Van Bergen
[1925], in the Dutch East Indies. These workers used " Bayer 205 " in combina-
tion with tartar emetic or atoxyl, in fractional or large doses. When used in frac-
tional doses, the dosage of " Bayer 205 " ranged from ½ to 2 grms. and in one