94     THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY [ III, I

instance a total of 10 grms. each of " Bayer 205 " and atoxyl was administered in
this manner. In the large-dose treatment, the drugs were administered in doses of
3 grms. each. In a recent paper, Bubberman [1931] recommends the treatment of
infected horses by the " simultaneous injection of 3—3½ grms. Naganol and
3—3½ grms. atoxyl per 150—200 kg. body-weight " and the author believes that
" if treatment is begun in the early stages of infection, 60 per cent. of recoveries
may be expected in equines ".

Bakker [1925] records having treated two infected horses with " Bayer 205 "
and tartar emetic and two others with atoxyl in addition to these drugs. The
" Bayer 205 " was administered in doses ranging from 1 to 4 grms. until a total
of 4 to 9.2 grms. had been given. The tartar emetic was administered in doses of
½ or 1 grm. until a total of 3 to 4 grms. had been reached, whilst the doses of
atoxyl given were 2½ and 3 grms. with totals of 3 and 5½ grms. Two of the treated
horses developed paresis about 2 months after treatment, but without the occur-
rence of trypanosomes in the blood. The remaining two horses regained condition
and did not relapse during a post-treatment observation period extending over some
months.

According to Hornby [1931], " the best results [in the treatment of equine
surra] are obtained with ' Bayer 205 ' alone or in conjunction with another drug, as
tartar emetic, antimosan, sulfarsenol, etc.".

Of workers in the Indian region, Mitchell in Burma would seem to favour the
combination of " Bayer 205 " with tartar emetic, for according to him " Naganol
+ Tartar Emetic will give a temporary immunity lasting a couple of months ". He
further writes : " It is hoped that repeated inoculations on these lines on two or more
occasions will carry the animals through the dangerous period (rains) and aid in
reducing the mortality resulting from the disease " (Annual Report of the Veteri-
nary Department of Burma for the year ending March 1930).

During the past five years, some trials have been carried out in the Punjab in
the treatment of natural cases of equine surra, using " Bayer 205 " in conjunction
with tartar emetic, and the results would appear to have been very satisfactory, as
is illustrated by the fact that, in one instance, " 14 out of 17 ponies [i.e., 82.4 per
cent.] subjected to this method of treatment were cured and discharged " [ Kahan
Singh, 1928]. In this connection, the following six protocols (kindly supplied by
the Director of Veterinary Services, Punjab) are of interest as furnishing some
indication of the actual method of treatment employed in individual cases :—

1. Horse No. 23. Age 10. Very poor. Paralyzed.
             8.IX.30. Injected 100 c.c. of a 2 per cent. solution of " Bayer 205".
            13.IX.30. Injected 100 c.c. of a 1 per cent. solution of tartar emetic.