CURATIVE TREATMENT OF SURRA IN EQUINES                                                     97

                                                                    TABLE II—contd.
                                     Treatment by combined intravenous-intrathecal injections—contd

Serial No.

Animal


Date of
infectives
inoculation.

Dose of "Bayer 205" in grammes
per 1,000 lb. body-weight

Result

Remarks

Intravenous

Intrathecal

13

Horse No. 63

14th Nov. 1925

5.0 Nov. 24th

0.02 Nov. 24th

Died 14th April
1926 with severe
symptoms of colic
but evidently cied
of reinfection
with surra.

Relapsed 11th April 1926 with
tryps. in circulating blood up
to 13th April but absent on day
of death. Spinal fluid not
examined.

14

Pony No. 85

27th Nov. 1925

5.0 Dec. 5th
5.0 Jan. 4th

0.02 Dec. 5th
0.03 Jan. 4th

Died 21st January
1926 of pleuro-
pneumonia.

Infected intrathecally. No para-
sites in blood between drug
injections. Spinal fluid not
examined.

15

Pony No. 77

27th Nov. 1925

2.5 Dec. 5th
2.5 Jan. 4th

0.02 Dec. 5th
0.02 Dec. 21st
0.02 Jan. 4th

Cured

Infected intrathecally. Never
relapsed during treatment.

16

Pony No. 78

27th Nov. 1925

Treated as

above

Cured

Ditto ditto.

17

Pony No. 86

27th Nov. 1925

Ditto.

Cured

Ditto ditto.

18

Pony No. 84

27th Nov. 1925

5.0 Dec. 5th
5.0 Jan. 4th

0.02 Dec. 5th
0.02 Dec. 21st
0.02 Jan. 4th

Cured

Ditto ditto.

19

Horse No. 45

5th Oct. 1925 .

5.0 Nov. 7th

0.02 Nov. 7th

Died 12th Novem-
ber 1925 evidently
of surra.

Tryps. in spinal fluid as also in
circulation on 7th November
1925. After this date spinal
fluid not examined and tryps.
absent in circulation.

20

Horse No. 70

4th Sept. 1925

5.0 Sept. 23rd
5.0 Oct. 23rd

0.02 Sept. 23Td
0.02 Oct. 23rd

Died 2nd Novem-
ber 1925 evidently
of causes other
than surra.

Tryparsamide used for intra-
thecal injection. Tryps. absent
in both spinal fluid and general
circulation since the date of
first injection of the drug.

21

Pony No. 76

27th May 1925

2.5 Dec. 5th
2.5 Jan. 4th
5.0 Mar. 4th

5.0 July 31st

0.02 Mar. 4th
0.02 July 30th

Died 12th August
1926 evidently of
surra.

Relapsed 15th February 1926 and
on 27th April 1926. Centrifuged
cerebrospinal fluid showed
tryps. 5 per field on 30th July
1926. The animal had been
infected intrathecally.

An examination of the foregoing Table shows that of the 19 animals treated by
the combined method, 3 died of surra and 2 others died of causes other than surra,
so that, leaving the latter two cases out of consideration, the percentage of recover-
ies amounted to 82.4 (14 out of 17) or, more precisely, 88.2 (15 out of 17), if Horse
No. 63 is regarded as a case of re-infection and not one of relapse. Nine animals
received only single (combined) injections of the drug, and of these, only one
(Horse No. 45) failed to be cured of surra, death in this case having been evidently
due to the invasion of the cerebrospinal system by surra parasites, although these
were not encountered in the circulating blood of the animal prior to death. The
recoveries in the case of animals treated by single injections amounted therefore
to 88.9 per cent. (8 out of 9), Horse No. 63 being regarded, as already mentioned,