296 THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY [III, III.

able effect on the liver, whereas carbon tetrachloride does cause necrosis of the
liver, even though there may be no external symptoms. Again quoting from
Drs. Lamson, Robbins and Ward⁴ :

Dogs have been given doses of tetrachlorethylene up to 4 c.c. per kilo at
intervals of 2 or 3 days for a period of several months without producing any
pathological changes in the liver.

Dizziness and incoordination of muscular movement may occasionally follow
the administration of tetrachlorethylene, but as a rule such symptoms
disappear rapidly, leaving no after effects. According to Lamson,
Robbins and Ward⁴, dizziness following the administration of tetrachlorethylene
is probably due to either exceptionally large doses or to the presence of oily or fatty
food in the gastor-intestinal tract at the time of treatment. Oily or fatty foods,
therefore, should be excluded from the diet twenty -four hours or so prior to the
administration of tetrachlorethylene, and for several hours afterwards, to prevent
absorption of the drug from the intestine. Under ordinary circumstances, there
being no oils or fats in the intestinal tract, tetrachlorethylene does not seem to be
absorbed in dogs even when administered in relatively large doses. Again quoting
Lamson, Robbins and Ward⁴ :

If normal dogs are given doses of tetrachlorethylene up to approximately 10 c.c.
per kilo, or fifty times the therapeutic dose, no indication of the absorption of the drug
in appreciable amounts is to be observed.

   THE EFFECTS OF TETRACHLORETHYLENE IN CASE OF CALCIUM DEFICIENCY.

Some writers appear to be of the opinion that tetrachlorethylene is dangerous
in cases of calcium deficiency ; but this opinion does not appear to have been
sustained by proof. According to Minot⁵, ' carbon tetrachloride does produce
some ill effect in dogs and other animals with low calcium balace ' but tetra-
chlorethylene does not seem to have such action, at least in domestic animals.
Lamson, Robbins and Ward administered tetrachlorethylene to cats and dogs pre-
viously fed on a diet deficient in calcium, and no ill effects followed. Similar
results were obtained by Schlingman in treating dogs with tetrachlorethylene, which
had previously been prepared by being fed on a calcium deficient diet.

As far as sheep or goats⁶ are concerned, tetrachlorethylene does not appear
to have any injurious effect on them because treatment has been given at monthly
intervals under carefully controlled experimental conditions for a period of over a
year without any appreciable ill results.

Deaths have followed the administration of 1 c.c. of carbon tetrachloride when
given for the removal of liver fluke in sheep, but the reason for such deaths has
not yet been clearly established. Dr. Robert Jay, in discussing an article by