CURATIVE TREATMENT OF SURRA IN BOVINES                     225

of any febrile symptoms and were characterized by the appearance of the parasites
only. This would appear to be in striking contrast with what one observes
in the case of equine surra, in which the succession of parasitic relapses is almost
invariably associated with elevation of body temperature.

In regard to the animals treated with Naganol, a single injection of the drug,
administered at the rate of 5 grms. per 1,000 lb. body weight, invariably resulted
in a complete sterilization of the circulating blood, as judged by the results of blood-
smear examination and of periodical sub-inoculation of blood into small animals
(Table II). In all cases, the parasites disappeared from the circulating blood with-
in 24 hours of the injection of the drug (Figs. 2 and 3) and did not appear again
during the observation period of (in the majority of cases) one year and a half.
It is to be mentioned, however, that Buffalo No. 1574 died of enteritis and debility
about 11 months prior to the date (December 20, 1933) on which it was due to be
discontinued and that no opportunity, therefore, occurred for testing the infectivity
of its blood on a susceptible equine subject. Nevertheless, the post-treatment
period of about eight months and a half during which it was kept under observation
would appear for all practical purposes to be sufficiently long for assessing the
value of the remedy in this case.