336 THE INDIAN JOURNAL OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY [VI, IV

along with other symptoms, by the end of four weeks. Ova began
to re-appear 18 weeks after the first injection. The animal was
again treated with the same dose of antimosan which caused them
to disappear in about ten days. The animal appeared clinically
cured.

On 12th August 1935, this animal was selected to try the effect of
progressively larger doses of tartar emetic. It was first given 3.75
grains of that drug per 100 lbs. body-weight in one dose. Three days
later, it was given 5.6 gains per 100 lbs. body-weight and within 12
hours the animal died. This animal showed a rise in temperature to
103°F. within 24 hours after the first injection, was dull and off-feed
during that period. On post-mortem examination, no schistosomes
were found, but endo-carditis and congestion of the intestinal mucous
membrane were noticed. It would appear, therefore, that a dose of
3.75 grains per 100 lbs. body-weight of the drug may produce a
reaction in cattle and is unsafe to repeat it during the period of
reaction.

Heifer No. 11.—Weight 196 lbs. Age 3 years. Duration of disease 1½
years. This animal was first treated with Trypaflavin and since no
improvement was noticed, it was given Antimosan from the 25th
April 1935. It showed large lesions and snoring was pronounced.
Ten ova on an average were seen in 0.1 c.c. of the discharge. It
was injected with 5 c.c. of the drug (or 2½ c.c. per 100 lbs. body-
weight) every alternate day till three doses were given. No im-
provement was noticed during the four weeks after treatment. It
was again injected in the first week of June, with 15 c.c. (or 7½ c.c.
per 100 lbs. body-weight) every alternate day till three doses were
given. At the end of four weeks the symptoms abated, and ova
disappeared. There was no relapse till the 17th August 1935 when
the period of observation terminated. The animal weighed 253 lbs.
at the end of the experiments. It received in all, 15 c.c. or nearly
14 grains of Antimosan in the first instance and 45 c.c. or about
42 grains in the second course.

Group C.—This group consisted of three animals which were treated with
Trypaflavin.

Bullock No. 8.—Weight 252 lbs. Age 7 years. Duration of disease 3 years.
It showed about 10 ova on an average in 0.1 c.c. of nasal discharge.
It was injected intravenously with 3 grains of Trypaflavin in
10 c.c. of water daily for 9 days. No improvement was noticeable
during a period of 5 weeks and ova continued to appear. It is in-
teresting to note that this animal developed acute hepatitis during