TREATMENT OF BOVINE NASAL SCHISTOSOMIASIS          343

results of Roy Chowdhury [ 1932 ] cannot be said to be conclusive in as much as
the animals he treated with Antimosan were not under his observation for a
sufficiently long time, nor was it possible for him then, to appreciate the results
of treatment by laboratory methods as can now be done, since the etiology of the
disease is known. Roy Chowdhury opines that recently infected animals require
only one dose for a cure. It is doubtful, if, in the treatment of this disease, the
administration of a single large dose of any drug will effect a cure and the
reasons are obvious. Another interesting observation is that recovery was
definite in those animals which received, at short intervals, doses almost equal
to those recommended by the makers of the drug. It would appear, therefore,
that the proper dose of the drug is the one that has been recommended by the
makers repeated at intervals of 2 or 3 days until about 4 injections are given.

                      Discussion on the Treatment of Trypaflavin

Trypaflavin is the same as Acriflavin. This drug was tried, because Fisher
[ 1934 ] reported, that he obtained with Acriflavin, some amount of success in the
treatment of intestinal schistosomiasis in the human being. He gave the drug
orally and no toxic manifestations seem to have been developed.

Trypaflavin was found to be useless in the treatment of bovine nasal schisto-
somiasis and on the other hand, it was noticed that the drug when given intra-
venously for some time, has harmful effects on the liver.

                Cost of treatment with tartar emetic and Antimosan

The cost of a pound of tartar emetic is about Rs. 1-8-0 and the cost of the
full course of 6 injections for an animal weighing 450 lbs. at 1.5 grains per 100
lbs. body-weight is 1.5 pies. This drug, therefore, is so cheap that nearly 200
animals of average weight may be treated at a cost of Rs. 1-8-0, when compared
with that of Antimosan which is about Rs. 2-8-0 for one animal for a course of
treatment recommended by the makers.

                                                SUMMARY

1. Antimonium tartaratum, Antimosan and Trypaflavin were given a trial
in treating cases of bovine nasal schistosomiasis.

2. Trypaflavin was found to be useless. Antimosan appears to be safe and
effective if given according to the instructions of the makers, but expensive.

3. Antimonium tartaratum is effective and cheap. The dose recommended
is 1.5 grains for every 100 lbs. body-weight of the animal repeated daily for six
days, or 2.5 grains every alternate day.

4. Any dose exceeding 3.5 grains per 100 lbs. body-weight seems to be
dangerous particularly, if repeated.