KARAM CHAND                                     269

copper sulphate. This combination was tried under the name of Govern-
ment Wire Worm Remedy (G. W. W. R.) in South Africa where good results
are claimed by Veglia [1928]. It is thought that the good results are mainly due
to the closure of the oesophageal groove enabling the drug to pass directly into
the abomasum. McEwen [1935] treated some lambs with copper sulphate
and nicotine sulphate and kept some as controls. He states that, of the treated
lot 8.3 per cent died, while of the entire control group 47 per cent died. He
feels that nicotine sulphate is better than copper sulphate when used alone ;
and it is suggested that the mixture owes its efficacy to the action of copper
sulphate in carrying the dose direct to the abomasum.

In this experiment it was noticed on faecal examination that the animals
were passing the eggs of Haemonchus, Oesophagostomum and Trichuris spp.
Some of them were occasionally passing tapeworm eggs which stopped
spontaneously without any treatment. Sometimes coccidia oocysts were
noticed, particularly in sheep. Accordingly, the treatment had to be confined
to the nematode worms, and the following drugs were tried :—

     1.  Single drugs:

          (a) Butea, powdered.

          (b) Copper sulphate.

          (c)  Kamala.

          (d)   Melon pumpkin seeds.

          (e)  Spineless cactus.

          (f) Turpentine oil.

          (g) Vernonia anthelmintica.

     2.  Combinations :

          (a) Butea with kamala.

          (b) Butea with embelia infusion.

          (c)  Copper sulphate with kamala.

          (d)   Copper sulphate with sodium arsenite.

          (e)  Ferrous sulphate with aloes.

          (f) Ferrous sulphate with pot. ant. tartrate.

GENERAL PROCEDURE FOR THE ADMINISTRATION OF ANTHELMINTICS

The animals were fasted for twenty-four hours prior to the administration
of anthelmintics, and food and water were withheld for twelve hours fol-
lowing the administration.