Surra.                                         25

establish a more correct dose of orpiment and better methods
of administration.

That a combination of tartar emetic, atoxyl and orpi-
ment, and also a combination of atoxyl, orpiment and
sodium arsenite, can be used with success.

In the outbreak of Surra among the Native Cavalry two
advanced cases were treated by Lieut. Anderson, A.V.C. In
one case abscesses developed at the seat of the atoxyl inocula-
tion and the horse was destroyed. The second case, Horse
245, had a relapse after treatment. Larger doses of atoxyl
and orpiment were then administered with apparent success.

In a new series of experiments at present under observa-
tion, the combination of atoxyl, sodium arsenite and orpi-
ment has given results superior to any other treatment. The
drugs are administered on successive days and repeated twice
after an interval of four and eight days. The animals showed
no ill effects from the treatment and rapidly improved in con-
dition. At the present time (six weeks) there has been no
reappearance of the trypanosomes.

                     GUINEA-PIG NO. 277.

Body weight
in grammes.

July 23rd ... Inoculated with Surra ......

550

Aug. 3rd ... ... Tryps. appeared in blood

520

„ 4th to 5th ... „ present.

520

„ 6th to 8th ... „ absent.

530

„ 9th to 14th ... „ present

580

„ 14th ... 1.5 c.c. of 1% Atoxyl „ „

580

„ 16th ... 9 mgms. of Orp. „ absent.

600

„ 18th ... 1.5 cc. of 1% Atoxyl „ „

610

„ 20th ... 9 mgms. of Orp. „ „

580

„ 22nd ... 1.5 c.c. of 1% Atoxyl „ „

600

„ 24th ... 9 mgms. of Orp. „ „

600

„ 26th ... 1.5 c.c. of 1% Atoxyl „ „

600

„ 28th ... 9 mgms. of Orp. „ „

600

„ 30th ... l.5 mgms. of Orp. „ „

620

Sept. 1st ... 9 mgms. of Orp. „ „

620

Nov. 12th ... ... „ „

640

                     GUINEA-PIG NO. 278.

Body weight
in grammes.

July 23rd ... Inoculated with Surra ......

600

„ 31st ... ... Tryps. appeared in blood

600

Aug. 1st to 9th ... „ present

500