12                                     SURRA.

of Dr. Hartley, Physiological Chemist, in questions connected
with Chemistry.

The Bulletin of the Bureau of Sleeping Sickness has been
extensively used for purposes of reference to other works on
trypanosomiasis.

TOXIC DOSE OF ARSENIOUS ACID, SOAMIN AND
                                    ATOXYL.

                          ARSENIOUS ACID.

The toxic dose for the horse is said to be (Law) 140 grains
in solution or 14 grammes in solid form; (Kaufmann) 3.4
grammes in solution or 45 grammes in solid form; Trélut
administered 3 to 6 grammes daily in treatment for Dourine.

In our experiments it was found that ponies of about
300 lbs. could tolerate repeated doses of 1 gramme without
ill-effect; that a dose of 2 to 3 grammes was fatal for ponies
of this weight; that horses weighing from 900 to 1,000 lbs.
could not tolerate more than 3 grammes. The arsenious acid
was administered after feeding.

Toxic dose is 2 to 3 grammes for ponies, and 4 to 5 grammes
for horses.

Arsenious acid administered in solution (Loeffler and Rueh)
has a more toxic effect than when given in bolus. One gramme
in solution is fatal for ponies weighing 250 lbs.

This is shewn in the following table:—