5

In milch cows, almost one of the first symptoms is a diminution in
the yield of milk, which becomes serous in character and small in
quantity or altogether arrested. The increase of temperature and the
disturbed lactation are the only symptoms noticed for from 24 to 48
hours.

The urine becomes deeper in colour, containing more solids. Urea is
much increased in quantity.

The disease remains for a short time characterized by these vague
symptoms, then its course rapidly advances, and, during the next three or
four days, more or less marked symptoms appear.

The temperature, elevated at first, does not maintain the same alti-
tude during the whole course of the disease. It soon descends either
because some improvement has taken place, which is rare, or because
the subject becomes very rapidly weakened. The surface temperature is
irregular, the ears and extremities becoming cold. The sick animal
soon falls into a state of somnolence, stupor and coma; the eyes are
lustreless and half-covered by the drooping lids. The conjunctivæ
are reddish-yellow in colour, either uniform or darker in patches and
ecchymosed; it is always the seat of a hypersecretion, which shows
itself at first by a limpid flow from the eyes, to which soon succeeds, in
a progressive manner, a yellow discharge, which by degrees becomes
purulent, greenish in colour, and irritates the skin over which it flows.

As the animal becomes fatigued, the erect position becomes pain-
ful, and the sick generally asume the recumbent one and remain
down.

The skin is hot, congested, and dry; sometimes it is covered with
sweat, more particularly in certain regions, as at the base of the
ears, etc.; the epidermis exfoliates and is easily detached; the hairs are
erect; the general sensibility is exaggerated. In white-skinned animals
we notice the congested appearance better, as the skin assumes a brick
red colour. We may observe trembling and shivering of certain groups
of muscles, and as the disease progresses the animal may shake. When
the disease is of some considerable duration, locomotion becomes painful
and difficult.

With regard to the digestive apparatus and the function of digestion
we observe numerous symptoms in connection with them.

Inappetence becomes in most cases complete, but not always;
rumination is suspended; eructations of gas are of frequeut occurrence.
The mouth soon exhales a fœtid odour; the buccal mucous membrane
is swollen, hyperæmic, and hot; the tongue becomes furred, congested
and red coloured, more particularly on its borders and inferior face. Sali-
vation is very abundant; the saliva at first clear and limpid becomes
greyish, thick yellow, viscous, fœtid, flocculent and sometimes sanguino-
lent; it flows from the lips, carrying with it pellicles plaques, grains or