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want pustule." Sometimes cases of internal charbon, bronchopulmo-
nary or intestinal, show themselves, following the introduction of
germs into the digestive or respiratory passages. External charbon,
which follows the accidental inoculation of the virus at any point of
the surface of the body, is observed in those persons who manipulato
fresh charbonous material, or materials containing the spores; it is
observed in veterinary surgeons, butchers, horse-slaughterers, herdsmen,
etc., and persons who make post-mortem examinations of animals
which have died from the malady, or who have manipulated the debris:
it has also been met with in persons working in wool, hides,
horns, etc. Wounds, punctures, excoriations, and scratches which may
exist previously or occur at the time of manipulating charbonous
materials, may serve as the point of entry of the bacillus or its spores.
It may sometimes happen that the contact or the bites of flies which
have frequented charbonous carcasses or material may give rise to local
charbon.

The bacilli, inoculated into any part of the body whatsoever,
multiply, causing at their point of entry a local lesion; then around
this lesion a swelling appears, and œdema which is hot and painful
and gradually extends. Then the malady becomes general. The germs
penetrating the walls of the vessels, or gaining access to the circulation
by means of the lymphatic system, are carried to the various organs
of the body. The general symptoms which have already appeared,
following the development of the local lesion, now become doubled in
intensity. The fever becomes very severe, the temperature is elevated,
the thirst intense; there is general malaise, headache, and nausea;
vomition and diarrhœa occur; then follow prostration, coma, asphyxia
black colour of the skin, convulsions, trismus, tetanus, etc., etc.

We may recognize three successive periods in the evolution of
malignant pustule. From the moment of inoculation to the time of
the appearence of the first symptom of the disease one, two, three,
or sometimes more days pass. The first period is characterized by prick-
ing and itching at the seat of inoculation, soon after which a small
phlyctenoid tumour, red at its periphery, and brownish black at the
centre, filled with a brown serosity, and soon surrounded or studded
around with small fine vesicles, appears. During the second period,
the tumor becomes indurated at its base, livid, black, and forms a scab.
At the same time the tissues surrounding the eschar become tumified,
swollen and œdematous, red or livid in colour, and sometimes covered with
small pblyetenæ with reddish-coloured contents. In the third phase, the
eschar extends, as does also the peripheric œdema, which invades the
arms, neck, trunk, face, etc., and is accompanied by swelling of the